What's New

Experimental validated microRNA target are to be added to IPA Fall 2011, including:

• miRecords: all 2,600 experimentally validated human, rat, and mouse microRNA-mRNA interactions
• Literature Findings: 13,100 microRNA-related Findings manually curated from published literature by Ingenuity scientific experts

IPA 9.0 features:

A brand-new microRNA analysis workflow  

• Identify mRNA targets for microRNAs from TargetScan and TarBase
• Explore the related biological context of microRNA-mRNA pairs
• Filter microRNA-mRNA pairs based on relevant biological characteristics
• Integrate microRNA and mRNA data with other types of datasets for elucidating biological impacts
  

An improved RNA-seq workflow

• Directly upload processed RNA-Seq datasets into IPA by RefSeq, Ensembl, and UCSC IDs

For more information:

• IPA news page
• What's New in IPA 9.0 Webinar
• MicroRNA Scientific Seminar
• RNA-seq Scientific Seminar

Main Applications

• IPA Core Analysis: Identify signaling and metabolic pathways, molecular networks, and biological processes that are most significantly perturbed in a dataset of interest.
• IPA-Metabolomics: Gain biological insight into cell physiology and metabolism from metabolite data.
• IPA-Tox: Analyze toxicity and safety of candidate compounds to better understand pharmacological response, drug mechanism of action, and mechanism of toxicity.
• IPA-Biomarker: Identify the most promising and relevant biomaker candidates within experimental datasets.
• Path Designer: Transform customized networks and pathways into publication-quality pathway graphics.

Noteworthy Features

• All-in-one web-based application provides easy and flexible accesses, as well as facilitates collaboration and results sharing.
• High quality, human curated knowledge database for functional and systematic analysis of data derived from gene expression and SNP microarrays, metabolomics and proteomics experiments, and smaller-scale experiments that generate gene lists.
• Enables search for targeted information on genes, proteins, chemicals, and drugs, and build interactive models of your experimental systems.
• Extensive library of well-characterized signaling and metabolic pathways offer a starting point for exploration and a bridge between novel discovery and known biology. Layer in novel insights, drugs, and 'omics data.
• Direct import of gene lists from microarray analysis software such as Partek Genomic Suite allows seamless integration of high throughput omics data.
• Accepts data from various experimental platforms such as gene expression, proteomics, genotyping, siRNA, miRNA, and Metabolimics. Supports all major commercial array platforms.
• Extensive knowledge database on model organisms human, mouse, rat and canine. Additional species supported via ortholog mapping.
• Interactively links external major databases in NCBI and other sources.
• Supports Windows and Macintosh OS, and fully compatible with major web browsers.